API omeprazole pellets powder CAS NO.73590-58-6

Name: API omeprazole pellets powder
SKU: 73590-58-6
Availability: InStock

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Basic information

Product Name:	Omeprazole
Synonyms:	1h-benzimidazole,5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulf;2-Chloromethyl-3,5-dinmethyl-4-methoxypyridine;5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazol;audazol;aulcer;belmazol;ceprandal;elgam
CAS:	73590-58-6
MF:	C17H19N3O3S
MW:	345.42
Product Categories:	Drug bulk;Active Pharmaceutical Ingredients;Omeprazole;Intermediates & Fine Chemicals;Pharmaceuticals;API's;ATPase;Metabolite Reference Standard;Isotopically Labeled Pharmaceutical Reference Standard;OSMITROL;Other APIs;Digestive System
Mol File:	73590-58-6.mol

Chemical Properties

melting point	156°C
boiling point	599.991 °C at 760 mmHg
density	1.371 g/cm3
flashing ponit	316.663 °C
storage temp.	2-8°C
solubility	H2O: 0.5 mg/mL
stability	Stable, but hygroscopic and photosensitive. Incompatible with strong oxidizing agents. Store in the dark.

Usage And Synthesis

Chemical Properties	White Crystalline Solid
Usage	Binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative
	diuretic, sweetener, diagnostic aid
	A selective proton pump and CYP inhibitor
	Omeprazole Pellets are used in the treatment of Gastroesophageal reflux disease (GERD): A condition in which backward flow of acid from the stomach causes heartburn and injury of the food pipe (esophagus)
Biological Activity	H + ,K + -ATPase inhibitor (IC 50 = 5.8 μ M) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC 50 = 0.16 μ M for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro . Also inhibits CYP2C19, CYP2C9 and CYP3A (K i values are 3.1, 40.1 and 84.4 μ M respectively) and blocks swelling-dependent chloride channels (ICIswell).