China (Mainland)
Premiumsupplier
Top Quality Sorafenib CAS 475207-59-1 Sorafenib Tosylate CAS NO.475207-59-1
- Min.Order: 100 Gram
- Payment Terms: L/C,T/T,
- Product Details
Keywords
- 475207-59-1
- Sorafenib
- Sorafenib Tosylate
Quick Details
- ProName: Top Quality Sorafenib CAS 475207-59-1 ...
- CasNo: 475207-59-1
- Molecular Formula: C28H24ClF3N4O6S
- Appearance: white powder
- Application: Ultra high quality API
- DeliveryTime: as customers request
- PackAge: 25kg /bag
- Port: any port in China
- ProductionCapacity: 1000 Kilogram/Month
- Purity: >99%
- Storage: Cool Dry Place
- Transportation: BY SEA OR BY AIR
- LimitNum: 100 Gram
Superiority
| 1)Quick Response Within 12 hours; |
| 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. |
| 3) OEM/ODM Available; |
| 4) Reasonable & Competitive Price; |
| 5) Fast Delivery: Samples from stock; bulk products within 7 days; |
| 6) Professional Documents for Your Clearance; |
| 7) Economic Freight Save Your Cost; |
| 8) All your money be refund immediately if quality issue happens. |
Details
Sorafenib tosylate
475207-59-1
Product Name: Sorafenib tosylate
Synonyms: SORAFENIB TOSYLATE;Sorafenib & its intermediates;Sorafinib mesylate;4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide monomethanesulfonate;Sorafenib Tosylate(Bay 43-9006,Nexavar);SORAFENIB TOSYLATE (BAY 43-9006 TOSYLATE);BAY 43-9006;BAY43-9006;4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N2-methylpyridine-2-carboxamide mono (4-methylbenzenesulfonate)
CAS: 475207-59-1
MF: C28H24ClF3N4O6S
MW: 637.0265696
EINECS: 641-758-8
General Description:
Sorafenib is available in 200-mg tablets for oral administrationand is used in the treatment of RCC and colon cancer.The agent is classified as a multikinase inhibitor because ofits action on numerous kinase enzymes including thePDGF-R, VEGF-R, Kit, and Raf. Sorafenib is 39% to 48% bioavailable and CYP3A4-mediated metabolism giveseight identified metabolites including the N-oxide, which isequally active with the parent. However, the majority of thedrug in plasma is present as the parent compound.Sorafenib is highly protein bound (99.5%). The drug iseliminated primarily in the feces (77%) with 19% appearingin the urine as glucuronides (UGT1A1) and has a eliminationhalf-life of 24 to 48 hours. The most commonly seentoxicity is skin rash that normally occurs within the first6 weeks of therapy. Other adverse effects include hypertension,fatigue, increased wound healing time, and increasedrisk of bleeding.
Uses: An inhibitor of Flk-1 (VEGFR), PDGFR and Raf kinases.