Competitive Price CAS 152044-53-6 Epothilone A,Epo A,Epothilones,Epothilon A CAS NO.152044-53-6

Product information:

(-)-epothilone a basic information
product name:	(-)-epothilone a
synonyms:	4,17-dioxabicyclo14.1.0heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1e)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (1s,3s,7s,10r,11s,12s,16r)-;epothilone-s;(1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-[(1e)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;epothile;4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione,7,11-dihydroxy-8,8,10,12-tetramethyl-3- [(1e)-1-methy;ixabepilone impurity 5 (epothilone a);(1s,3s,7s,10r,11s,12s,16r,e)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione;(1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-[(1e)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione epothilone a
cas:	152044-53-6
mf:	c26h39no6s
mw:	0
einecs:
product categories:	chiral reagents;inhibitors;intermediates & fine chemicals;pharmaceuticals;sulfur & selenium compounds
mol file:	152044-53-6.mol
(-)-epothilone a chemical properties
mp	95ºC
density	1.143
storage temp.	20°c
safety information
msds information
(-)-epothilone a usage and synthesis
usage	the epothilones are a novel class of antineoplastic agents possessing antitubulin activity. epothilone a, b isolated from sorangium cellulosum was associated with cell cycle arrest at g2/m transition and apoptosis that was resisted with overexpression of β-tubulin and p-glycoprotein in human bladder carcinoma cell.
usage	epothilone a is a microtubule inhibitor isolated from the myxobacteria, sorangium cellulosum. epothilone a acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the g2/m transition, leading to cytotoxicity. epothilone a has been investigated in clinical trials as an antitumour agent.
usage	epothilone a is a microtubule inhibitor isolated from the myxobacteria, sorangium cellulosum. epothilone a acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the g2/m transition, leading to cytotoxicity. epothilone a has been investigated in clinical trials as an antitumor agent.

Specification:

Product Description:

EpothiloneA was found in the celllosum of Myxobacteria Sorangiumcellulosum. It is a microtubule stabilizer similar to paclitaxel, which induces the polymerization of tubulin and leads to the cell cycle stopping at g2-M phase, which produces toxicity and also induces apoptosis. The EC0.01 value of EpothiloneA is 2μM. EpothiloneA effectively inhibited the proliferation of HCT116 cells with IC50 of 4.4nM. EpothiloneA acts on KB3-1,KBV-1,Hela, and Hs578T cells and has cytotoxic Chemicalbook with IC50 ranging from 13nM to 160nM. EpothiloneA is more water-soluble than paclitaxel, and it competitively binds to microtubules with IC50 of 2.3μM. However,EpothiloneA and Taxol do not share a pharmacophore, and they independently and specifically utilize their tubulin binding bags. The newly discovered Transformation of EpothiloneA caused by AspergillusnigerAS3.739 produced metabolites that were toxic to McF-7 cells but had very high IC50 values.

Product Application and Function:

Epothilone, a class of macrolides, was first reported by G. Hoffle et al., National Center for Biotechnology (GBF), Germany, in chemical Book 993. Ebomycin was isolated from the fermentation broth of the suborder Myxobacteria, cystis fibrinosa. The main components of ebomycin were EpothiloneA and B.