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Pharmaceutical Raw Materials 99%min Crizotinib Manufacturer for Anti-Cancer CAS 877399-52-5 CAS NO.877399-52-5
- Min.Order: 10 Gram
- Payment Terms: L/C,T/T,
- Product Details
Keywords
- 877399-52-5
- Crizotinib
- C21H22Cl2FN5O
Quick Details
- ProName: Pharmaceutical Raw Materials 99%min Cr...
- CasNo: 877399-52-5
- Molecular Formula: C21H22Cl2FN5O
- Appearance: white powder
- Application: API intermediate
- DeliveryTime: as customers request
- PackAge: 25kg/Drum 1kg, 10kg, 100kg, 200kg
- Port: any port in China
- ProductionCapacity: 100 Kilogram/Day
- Purity: >99%
- Storage: Shady, sealed, dry place
- Transportation: by sea or by air
- LimitNum: 10 Gram
Superiority
| 1)Quick Response Within 12 hours; |
| 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. |
| 3) OEM/ODM Available; |
| 4) Reasonable & Competitive Price; |
| 5) Fast Delivery: Samples from stock; bulk products within 7 days; |
| 6) Professional Documents for Your Clearance; |
| 7) Economic Freight Save Your Cost; |
| 8) All your money be refund immediately if quality issue happens. |
Details
Product Name:Crizotinib
CAS:877399-52-5
MF:C21H22Cl2FN5O
MW:450.343
EINECS:638-814-9
Mol File:877399-52-5.mol
Melting point:192 °C
Boiling point:599.2±50.0 °C(Predicted)
Density 1.47±0.1 g/cm3(Predicted)
storage temp. room temp
pka9.81±0.10(Predicted)
form powder
color white to tan
Application:
Crizotinib is a dual ATP competitive inhibitor of tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50=8 nM) and ALK (cellular IC50=20 nM), both of which are important targets for cancer chemotherapy. When crizotinib was tested for selectivity versus other kinases it was found to have enzyme IC50's within 100-fold multiples of c-MET for 13 of the 120 kinases tested. In cellular assays, crizotinib was found to inhibit RON (recepteur d'origine nantais) kinase with a 10-fold selectivity window over c-MET.
Chemical PropertiesWhite Solid
UsesA potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). A potential antitumor agent.
UsesCrizotinib is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.
UsesPF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley